CLASSIFICATION OF DRUG RECEPTORS DOWNLOAD

Receptor types, mechanism, receptor pharmacology, drug receptor interactions, theories of receptor pharmacology, spare receptors and new. to regulate Src kinases required for T- and B-cell antigen receptor signal transduction .. of STAT5A/B mRNA/protein is a mechanism for imatinib drug resistance. Pharmacol Rev. Sep;36(3) The classification of drugs and drug receptors in isolated tissues. Kenakin TP. PMID: ; [Indexed for MEDLINE].


CLASSIFICATION OF DRUG RECEPTORS DOWNLOAD

Author: Dayna Murray
Country: Micronesia
Language: English
Genre: Education
Published: 20 December 2017
Pages: 492
PDF File Size: 1.67 Mb
ePub File Size: 25.54 Mb
ISBN: 478-6-93189-371-9
Downloads: 42323
Price: Free
Uploader: Dayna Murray

CLASSIFICATION OF DRUG RECEPTORS DOWNLOAD


Theories of drug-receptor interaction[ edit ] Occupation[ edit ] The central dogma of receptor pharmacology is that a drug effect is directly proportional to the number of receptors that are occupied.

The classification of drugs and drug receptors in isolated tissues.

Furthermore, a drug effect ceases as a drug-receptor complex dissociates. The ability of a drug to combine with a receptor to create a drug-receptor complex.

The ability of a drug-receptor complex to initiate a response. Rate[ edit ] In contrast to the accepted Occupation Theory, Rate Theory proposes that the activation of receptors is classification of drug receptors proportional to the total number of encounters of a drug with its receptors per unit time.

Pharmacological activity is directly proportional to the rates of dissociation and association, not the number of receptors occupied: A drug with a fast association and a fast dissociation.

CLASSIFICATION OF DRUG RECEPTORS DOWNLOAD

A drug with an intermediate association and an intermediate dissociation. Spare Receptors[ edit ] In some receptor systems e. Thus, that system has spare receptors or a receptor reserve. This arrangement produces an economy of neurotransmitter production and release.

These are soluble cytosolic or classification of drug receptors proteins, to which the steroid molecule binds after crossing the cell membrane.

The classification of drugs and drug receptors in isolated tissues.

This complex is believed to unfold and expose the normally buried DNA binding domain, which recognises specific base sequences, thus activating particular genes.

The effects produced are as a result of increased classification of drug receptors synthesis, and thus are slow in onset. The different steroid hormones are able to activate different genes, and thus initiate completely different pattern of protein synthesis, and produce different physiological effects.

Thyroid hormones, glucocorticoids, mineralo-corticoids etc.

  • Classification of Receptors: 4 Types | Pharmacodynamics
  • Receptor (biochemistry) - Wikipedia
  • Receptor (biochemistry)

At present there are four main types of receptor classified according to the nature of the receptor-effector linkage, fig 3. Similarly, receptors and receptor subtypes exist for other agents.

CLASSIFICATION OF DRUG RECEPTORS DOWNLOAD

The number of any given receptor type or subtype on a cell may also vary.